Premature Ejaculation Treatment Selector
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Recommended Treatments
When men struggle with premature ejaculation is a sexual dysfunction that can damage confidence and relationships. The market now offers a handful of drug‑based options and non‑pharmacologic approaches, each promising a longer, more satisfying experience. If you’ve heard about Poxet (dapoxetine) and wonder how it stacks up against the rest, you’re in the right place. This guide walks through the science, the numbers, and the practical trade‑offs so you can decide which solution fits your lifestyle.
What is Poxet (Dapoxetine)?
Dapoxetine is a short‑acting selective serotonin reuptake inhibitor (SSRI) approved specifically for on‑demand use in premature ejaculation. Marketed as Poxet in several countries, it is taken 1-3hours before sexual activity, usually in 30mg or 60mg tablets. The drug was first authorized by the European Medicines Agency in 2009 and later gained approval in parts of Asia and Latin America.
How Dapoxetine Works
Dapoxetine boosts serotonin levels in key brain pathways that control ejaculatory latency. Because it has a half‑life of only about 1.5hours, the drug peaks quickly and clears from the system within a few hours, reducing the risk of lingering side effects that are common with daily SSRIs.
Clinical Efficacy and Safety Profile
Large‑scale, double‑blind trials show that dapoxetine increases the intravaginal ejaculatory latency time (IELT) by an average of 2-3minutes compared with placebo. Around 70% of users report a meaningful improvement in sexual satisfaction. The most frequent adverse events are mild nausea (≈10%), dizziness (≈8%), and headache (≈6%). Serious cardiac events are rare but the drug is contraindicated in patients with significant heart disease, uncontrolled hypertension, or on monoamine oxidase inhibitors.
Top Alternatives to Poxet
While Poxet excels at on‑demand dosing, several other options are widely used:
- Sertraline - a daily SSRI often prescribed off‑label for PE.
- Paroxetine - another daily SSRI with strong serotonergic effects.
- Clomipramine - a tricyclic antidepressant used in low doses for PE.
- Lidocaine spray or ointment - a topical anesthetic that reduces penile sensitivity.
- Behavioral therapy - techniques such as the stop‑start method, squeeze technique, and mindfulness‑based exercises.
Side‑by‑Side Comparison
| Drug/Method | Type | Typical Regimen | Onset of Effect | Avg. IELT Increase | Common Side Effects | Major Contra‑indications | US Approx. Price* |
|---|---|---|---|---|---|---|---|
| Poxet (dapoxetine) | Short‑acting SSRI | 30mg or 60mg 1‑3h before sex | 30‑60min | +2-3min | Nausea, dizziness, headache | Heart disease, MAO‑I use | $70‑$120 per pack (10 tablets) |
| Sertraline | Daily SSRI | 25‑100mg daily | 2‑4weeks | +1.5‑2min | Insomnia, sexual dysfunction | MAO‑I, severe liver disease | $15‑$30 per month |
| Paroxetine | Daily SSRI | 10‑30mg daily | 2‑3weeks | +1.8‑2.5min | Weight gain, fatigue | MAO‑I, QT prolongation | $20‑$35 per month |
| Clomipramine | Tricyclic antidepressant | 25‑50mg daily | 1‑2weeks | +1‑1.5min | Dry mouth, constipation | Heart block, glaucoma | $30‑$45 per month |
| Lidocaine spray | Topical anesthetic | Apply 5‑10min before sex | Immediate | +0.5‑1min | Local irritation, allergic reaction | Penile skin lesions | $25‑$40 per bottle (10mL) |
| Behavioral Therapy | Non‑pharmacologic | Practice 2‑3times/week | Weeks‑months | +0.5‑2min (varies) | Frustration, need for partner involvement | None (except motivation) | Free‑to‑low cost (sessions $80‑$150) |
*Prices are average retail figures for 2025 in the United States and can vary by pharmacy and insurance coverage.
Choosing the Right Option for You
Decision‑making boils down to three practical questions:
- Do I need on‑demand relief? If spontaneity matters and you can plan ahead, Poxet’s rapid onset is hard to beat.
- Can I commit to daily medication? Daily SSRIs like sertraline or paroxetine provide steady improvement but require a commitment of weeks.
- Do I want a non‑drug approach? Behavioral therapy and lidocaine work without systemic exposure, which is attractive for men with cardiac concerns or drug interactions.
Other factors to weigh include cost, insurance coverage, side‑effect tolerance, and any existing health conditions (e.g., heart disease, depression). Talk to a urologist or sexual health specialist to map these variables against your goals.
Practical Tips for Switching or Combining Treatments
- Wash‑out period: If moving from a daily SSRI to dapoxetine, discontinue the daily drug at least 5days before the first dapoxetine dose to avoid serotonin syndrome.
- Gradual titration: Start with 30mg of Poxet; if you experience nausea, increase the interval before sex or try the 60mg dose on a later occasion.
- Combine safely: Some clinicians pair a low‑dose daily SSRI with occasional lidocaine spray for added benefit, but always check for overlapping side effects.
- Monitor progress: Use a simple diary (date, dose, IELT, side effects) for at least four weeks to see real trends.
- Partner involvement: Successful behavioral therapy hinges on communication; schedule a brief chat with your partner before trying the squeeze technique.
Remember, none of these treatments are magic bullets. Persistence, proper dosing, and open dialogue typically yield the best outcomes.
Frequently Asked Questions
Can I take Poxet if I’m already on an antidepressant?
Mixing dapoxetine with other SSRIs or SNRIs can raise serotonin levels too high and trigger serotonin syndrome. Doctors usually recommend a 5‑day wash‑out before starting Poxet.
Is dapoxetine safe for men with mild hypertension?
Mild, well‑controlled hypertension isn’t a direct contraindication, but a physician should review any cardiovascular meds because dapoxetine can cause transient increases in heart rate.
How does the effectiveness of lidocaine spray compare to Poxet?
Lidocaine provides immediate desensitization but usually adds only half a minute to IELT, whereas Poxet can add 2‑3 minutes on average. The choice often comes down to side‑effect tolerance and personal preference.
Do daily SSRIs work for men who don’t have depression?
Yes. Off‑label use of sertraline, paroxetine or clomipramine is common for PE. They increase serotonin steadily, which can lengthen IELT after a few weeks, even without mood‑related benefits.
Is behavioral therapy effective on its own?
For many men, structured exercises (stop‑start, squeeze, mindfulness) yield 0.5‑2‑minute gains. Success rates rise when a partner participates and when the techniques are practiced consistently over several weeks.
James Lee
October 12, 2025 AT 02:05Wow, this is the literary equvalent of a placibo.
Dennis Scholing
October 12, 2025 AT 10:25Thank you for providing such a comprehensive overview. The inclusion of both pharmacologic and behavioral options assists readers in aligning treatment choices with personal preferences and clinical considerations. I appreciate the clear tabular comparison and the practical tips for transitioning between therapies, which are often overlooked in brief summaries.